Vikrant Palande

Hello, this is Vikrant. I am a PhD student at Bar Ilan University, Faculty of Medicine in the Galilee. My principal scientific interests are Cancer genomics and its diagnostic applications. I am involved in studying clinical relevance of cell-free circulating DNA (cfDNA) for diagnosis, staging, prognosis and therapeutic monitoring of Gliomas Tumors.

Understanding hematopoiesis from a single-cell standpoint: Kokkaliaris., et al. (2016).

 

The cellular diversity of the hematopoietic system has been extensively studied, and a plethora of cell surface markers have been used to discriminate and prospectively purify different blood cell types. However, even within phenotypically identical fractions of hematopoietic stem and progenitor cells or lineage-restricted progenitors, significant functional heterogeneity

Patients with genetically heterogeneous synchronous colorectal cancer carry rare damaging germline mutations in immune-related genes: Cereda et al (2016)

  Synchronous colorectal cancers (syCRCs) are physically separated tumours that develop simultaneously. To understand how the genetic and environmental background influences the development of multiple tumours, here we conduct a comparative analysis of 20 syCRCs from 10 patients. We show that syCRCs have independent genetic origins, acquire dissimilar somatic alterations,

Identification of neoantigen-specific lymphocytes for its direct use in cancer immunotherapy: another emerging application of liquid biopsy in Cancer treatment.

  A recent research letter in Nature Medicine by Alena Gros et al has opened a novel window for treatment of cancer tumors using personalized neoantigen-specific lymphocytes. In their study they have successfully identified patient-specific repertoire of tumor reactive CD8+ lymphocytes from peripheral blood. (a),
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