The cellular diversity of the hematopoietic system has been extensively studied, and a plethora of cell surface markers have been used to discriminate and prospectively purify different blood cell types. However, even within phenotypically identical fractions of hematopoietic stem and progenitor cells or lineage-restricted progenitors, significant functional heterogeneity
Synchronous colorectal cancers (syCRCs) are physically separated tumours that develop simultaneously. To understand how the genetic and environmental background influences the development of multiple tumours, here we conduct a comparative analysis of 20 syCRCs from 10 patients. We show that syCRCs have independent genetic origins, acquire dissimilar somatic alterations,
Recent breakthroughs in cancer immunotherapy and decreasing costs of high-throughput technologies have sparked intensive research into tumour-immune cell interactions using genomic tools. The wealth of the generated data and the added complexity pose considerable challenges and require computational tools to process, to analyse and to
‘Liquid Biopsy’ news around the world displaying that how patients are being convinced to go for this test than invasive tissue biopsy tests. This picture shows that this test will soon replace entire concept of tissue biopsy and will become common in the field of cancer diagnosis.
A recent research letter in Nature Medicine by Alena Gros et al has opened a novel window for treatment of cancer tumors using personalized neoantigen-specific lymphocytes. In their study they have successfully identified patient-specific repertoire of tumor reactive CD8+ lymphocytes from peripheral blood.
Isolation of cell-free circulating DNA (cfDNA) from blood and detection of presence of circulating tumor DNA (ctDNA) in it are two main parts of liquid biopsy diagnosis technique. The analysis of circulating tumor DNA (ctDNA) among total isolated circulating nucleic acid is challenging and requires highly sensitive techniques due
The entire picture of how cfDNA can be used as a footprint markers in liquid biopsy. [Shendure Lab/University of Washington]