Computational genomics and its key role in developing cancer immunotherapy

 

Recent breakthroughs in cancer immunotherapy and decreasing costs of high-throughput technologies have sparked intensive research into tumour-immune cell interactions using genomic tools. The wealth of the generated data and the added complexity pose considerable challenges and require computational tools to process, to analyse and to visualize the data. Recently, various tools have been developed and used to mine tumour immunologic and genomic data effectively and to provide novel mechanistic insights. Here, we review computational genomics tools for cancer immunology and provide information on the requirements and functionality in order to assist in the selection of tools and assembly of analytical pipelines.

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Source: Nature Reviews Genetics (2016)


References:
Hackl, H., Charoentong, P., Finotello, F., & Trajanoski, Z. (2016). Computational genomics tools for dissecting tumour–immune cell interactions. Nature Reviews Genetics.

About Vikrant Palande

Hello, this is Vikrant. I am a PhD student at Bar Ilan University, Faculty of Medicine in the Galilee. My principal scientific interests are Cancer genomics and its diagnostic applications. I am involved in studying clinical relevance of cell-free circulating DNA (cfDNA) for diagnosis, staging, prognosis and therapeutic monitoring of Gliomas Tumors.